Evaluation of inflammatory and hematological parameters in patients diagnosed with COVID-19.

INTRODUCTION: This study aims to research the effects of hematological and inflammatory parameters on the prognosis of COVID-19 disease and hospitalization duration. METHODOLOGY: One hundred and eighty-six patients with COVID-19 and a control group consisting of 187 healthy individuals were included in the study. Hematological variables and inflammatory parameters of the patients were recorded on the first and the fifth days of hospitalization. RESULTS: White blood cell count, lymphocyte count, and platelet count were statistically lower, and mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) levels were higher in the patient group compared to the control group. It was observed that the neutrophil count and MPV level were lower, and the platelet count and ferritin level were statistically higher on the fifth day of follow-up compared to the admission day. In contrast, there was a significantly positive correlation between the duration of hospitalization and the fifth day D-dimer (r = 0.546, p < 0.001) and ferritin (r = 0.568, p < 0.001); in addition, there was a negative correlation between the duration of hospitalization and admission day lymphocyte count and the fifth-day lymphocyte count. CONCLUSIONS: Increased levels of ferritin and D-dimer, and decreased count of lymphocytes are among the important factors affecting the duration of hospitalization for COVID-19 patients. Furthermore, we think that neutrophil count and MPV levels are low, and platelet count and ferritin levels are high during the disease. Therefore, these parameters can be used as prognostic indicators of the disease.

Which COVID-19 Patients Die in Intensive Care Unit (ICU) in Turkey

A comparison of deceased and surviving patients showed that being female, older than 62, and a smoker and having diabetes mellitus, hypertension, and/or coronary artery disease significantly increased mortality. Information about the patients' age, gender, comorbidities, duration of hospitalization, COVID-19-related lung tomography findings, hemogram parameters (white blood cell (WBC), neutrophil, lymphocyte, and platelet counts, haemoglobin level, neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR), biochemical parameters, and ventilatory support [mechanical ventilation, non-invasive mechanical ventilation (NIMV), high-flow oxygen (HFNO)] were retrospectively accessed in the hospital records. Since the first COVID-19 case was admitted on 15 March, 2020, a total of 618 patients have been diagnosed with COVID-19 in our hospital. The comparison of the deceased and surviving patients also displayed that smoking (p=0.004), diabetes mellitus (p=0.007), hypertension (p=0.042), and coronary artery disease (p=0.049) statistically increased mortality. In our study, the comparison of the laboratory parameters of the deceased and surviving patients showed that the platelet (p=0.006), white blood cell (p=0.048), and neutrophil counts (p=0.033), and NLR (p=0.010) and PLR (p=0.033) were significantly higher in the deceased group compared to the surviving group.

COVID-19 Erişkin Hasta Yönetimi

Clinical course;It ranges from asymptomatic infection to mild, moderate, and severe pneumonia, multi-organ failure and death. Asymptomatic cases serve an important source of transmission to individuals with comorbidities. Early recognition of the severity of the disease and aggressive supportive treatment are the most important aspects of patient management in patients with a diagnosis of COVID-19. In this article, adult patient management in the COVID-19 pandemic at Dicle University Faculty of Medicine is discussed.

COVID-19 Adult Patient Management

Coronavirus disease (COVID-19) is an infectious disease that causes serious respiratory diseases such as pneumonia and respiratory failure caused by the newly emerged coronavirus (SARS-CoV-2). Clinical course;It ranges from asymptomatic infection to mild, moderate, and severe pneumonia, multi-organ failure and death. Although the disease usually presents a mild or asymptomatic course in children and adolescents, severe cases have also been reported in this age group. Asymptomatic cases serve an important source of transmission to individuals with comorbidities. It is known that individuals with comorbidities such as elderly, diabetes mellitus, hypertension, lung and heart diseasesand individuals with immunosuppressive conditions such as transplantation and malignancy are in the risk group and can have severe disease. Early recognition of the severity of the disease and aggressive supportive treatment are the most important aspects of patient management in patients with a diagnosis of COVID-19. In this article, adult patient management in the COVID-19 pandemic at Dicle University Faculty of Medicine is discussed. (English) [ FROM AUTHOR] Koronavirüs hastalığı (COVID-19), yeni ortaya çıkan koronavirüsün (SARS-CoV-2) sebep olduğu pnömoni ve solunum yetmezliği gibi ciddi solunum yolu hastalıklarına neden olan bir enfeksiyon hastalığıdır. Klinik seyir;asemptomatik enfeksiyondan, hafif, orta veya ağır seyirli pnömoni, çoklu organ yetmezliği ve ölüme kadar değişiklik gösterir. Çocuk ve gençlerde genellikle hastalık hafif veya asemptomatik seyir gösterirken, bu yaş grubunda ağır seyirli vakalar da bildirilmiştir. Asemptomatik olgular, komorbiditesi olan bireylere bulaş açısından önemli bir kaynak görevi görürler. Özellikle ileri yaş, diabetes mellitus, hipertansiyon, akciğer ve kalp hastalıkları gibi komorbiditesi bulunanlar ile transplantasyon ve malignite gibi immunsüpresif durumu olan bireylerin riskli grupta yer aldığı ve hastalığı şiddetli geçirebildikleri bilinmektedir. COVID-19 tanılı hastalarda, hastalığın ciddiyetinin erken tanınması ve agresif destek tedavisinin sağlanması hasta yönetiminin en önemli noktasıdır. Bu makalede Dicle Üniversitesi Tıp Fakültesi'nde COVID-19 pandemisinde erişkin hasta yönetimi ele alınmıştır. (Turkish) [ FROM AUTHOR] Copyright of Dicle Medical Journal / Dicle Tip Dergisi is the property of Dicle Tip Dergisi/ Dicle Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)